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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737222
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1affects expressionEXP 6480464CTDTamoxifen affects the expression of CYP17A1 mRNAPMID:20937368
Cyp17a1decreases expressionEXP 6480464CTDTamoxifen results in decreased expression of CYP17A1 mRNAPMID:25123088
Cyp17a1increases response to substanceISOCYP17A1 (Homo sapiens)6480464CTDCYP17A1 gene polymorphism results in increased susceptibility to TamoxifenPMID:15706422
Cyp17a1multiple interactionsISOCyp17a1 (Rattus norvegicus)6480464CTD[bexarotene co-treated with Tamoxifen] results in increased expression of CYP17A1 mRNAPMID:17630414
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