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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628734
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfsf10
Name: TNF superfamily member 10
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfsf10multiple interactionsISOTNFSF10 (Homo sapiens)6480464CTD[Tamoxifen co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein; [Tamoxifen co-treated with TNFSF10 protein] results in decreased expression of CASP8 protein modified form; [Tamoxifen co-treated with TNFSF10 protein] results in decreased expression of CFLAR protein modified form; [Tamoxifen co-treated with TNFSF10 protein] results in decreased expression of TNFRSF10C protein; [Tamoxifen co-treated with TNFSF10 protein] results in decreased expression of TNFRSF10D protein; [Tamoxifen co-treated with TNFSF10 protein] results in increased cleavage of BID protein; [Tamoxifen co-treated with TNFSF10 protein] results in increased cleavage of CASP9 protein; [Tamoxifen co-treated with TNFSF10 protein] results in increased expression of BAX proteinPMID:17767197
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