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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3612
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ncor1
Name: nuclear receptor co-repressor 1
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ncor1multiple interactionsISONCOR1 (Homo sapiens)6480464CTDTamoxifen inhibits the reaction [[ESR1 protein binds to NCOR1 protein] which binds to TFF1 promoter]; Tamoxifen inhibits the reaction [ESR1 protein binds to NCOR1 protein]; Tamoxifen promotes the reaction [NCOR1 protein binds to TFF1 promoter]; Tamoxifen promotes the reaction [NCOR1 protein binds to TFF2 promoter]PMID:17157789 PMID:19858209 PMID:20696891 PMID:23665804
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