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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10765
Species: Mus musculus
RGD Object: Gene
Symbol: Igf1
Name: insulin-like growth factor 1
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1affects expressionEXP 6480464CTDTamoxifen affects the expression of IGF1 mRNAPMID:17555576
Igf1increases expressionEXP 6480464CTDTamoxifen results in increased expression of IGF1 mRNAPMID:19400957
Igf1decreases expressionISOIGF1 (Homo sapiens)6480464CTDTamoxifen results in decreased expression of IGF1 proteinPMID:20332317
Igf1increases expressionISOIgf1 (Rattus norvegicus)6480464CTDTamoxifen results in increased expression of IGF1 mRNAPMID:19400957
Igf1multiple interactionsISOIGF1 (Homo sapiens)6480464CTD[bicalutamide co-treated with Tamoxifen] results in decreased expression of IGF1 protein; Tamoxifen inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of IGF1 protein]; Tamoxifen inhibits the reaction [Estradiol results in increased secretion of IGF1 protein]PMID:15809018 PMID:16847815
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