GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | HMOX1 | increases expression | EXP | | 6480464 | CTD | 2-butenal results in increased expression of HMOX1 mRNA; 2-butenal results in increased expression of HMOX1 protein | PMID:20471460 PMID:21238556 PMID:28947239 | HMOX1 | multiple interactions | EXP | | 6480464 | CTD | [zinc protoporphyrin results in decreased activity of HMOX1 protein] which results in increased susceptibility to 2-butenal; Acetylcysteine inhibits the reaction [2-butenal results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [2-butenal results in increased expression of HMOX1 protein]; PRKCD protein promotes the reaction [2-butenal results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [2-butenal results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [2-butenal results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [2-butenal results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [2-butenal results in increased expression of HMOX1 protein] | PMID:21238556 | | ||||||||||||||||||||||
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