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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:41500
Term: 4-phenylbutyric acid
Definition: A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Chemical ID: MESH:C075773
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTD4-phenylbutyric acid results in decreased expression of DDIT3 protein

PMID:25450231, PMID:28698385
multiple interactionsEXP 6480464CTD4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein], 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of DDIT3 mRNA], 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of DDIT3 protein], 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of DDIT3 mRNA], 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of DDIT3 protein], 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of DDIT3 protein]

PMID:26804720, PMID:27578021, PMID:27638049, PMID:28245985, PMID:30602124
decreases expressionISORGD:623916480464CTD4-phenylbutyric acid results in decreased expression of DDIT3 protein

PMID:27484784, PMID:28844859
multiple interactionsISORGD:623916480464CTD4-phenylbutyric acid inhibits the reaction [6-chloro-2, 3, 4, 9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of DDIT3 mRNA], 4-phenylbutyric acid inhibits the reaction [6-chloro-2, 3, 4, 9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of DDIT3 protein], 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of DDIT3 mRNA], 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of DDIT3 protein], 4-phenylbutyric acid inhibits the reaction [Oxygen deficiency results in increased expression of DDIT3 protein], 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of DDIT3 protein], 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of DDIT3 mRNA], 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of DDIT3 protein], 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of DDIT3 protein], 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of DDIT3 protein], 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein], 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of DDIT3 protein]

PMID:25450231, PMID:26804720, PMID:27484784, PMID:28063906, PMID:28844859, PMID:29653943, PMID:30980806
multiple interactionsISORGD:691656480464CTD4-phenylbutyric acid inhibits the reaction [Acrylamide results in increased expression of DDIT3 mRNA], 4-phenylbutyric acid inhibits the reaction [leflunomide results in increased expression of DDIT3 protein], 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of DDIT3 protein], 4-phenylbutyric acid inhibits the reaction [nefazodone results in increased expression of DDIT3 protein], 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of DDIT3 protein], 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of DDIT3 mRNA], 4-phenylbutyric acid inhibits the reaction [Sertraline results in increased expression of DDIT3 protein], 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased expression of DDIT3 protein], 4-phenylbutyric acid inhibits the reaction [tris(1, 3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein], 4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1, 3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]], Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1, 3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]]

PMID:24865413, PMID:27470132, PMID:27613715, PMID:27634458, PMID:27816613, PMID:28063906, PMID:28245985, PMID:28988120, PMID:29981725
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.