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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:41500
Term: 4-phenylbutyric acid
Definition: A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Chemical ID: MESH:C075773
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13480776480464CTD4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of CASP12 protein]

PMID:28245985
multiple interactionsISORGD:7314426480464CTD4-phenylbutyric acid inhibits the reaction [arsenic trioxide results in increased expression of CASP12 protein modified form], 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of CASP12 protein], 4-phenylbutyric acid inhibits the reaction [Rotenone results in increased activity of CASP12 protein]

PMID:17459145, PMID:27638049, PMID:28245985
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.