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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3070
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnajb9
Name: DnaJ heat shock protein family (Hsp40) member B9
Acc ID: CHEBI:41500
Term: 4-phenylbutyric acid
Definition: A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Chemical ID: MESH:C075773
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnajb9decreases expressionISODnajb9 (Mus musculus)6480464CTD4-phenylbutyric acid results in decreased expression of DNAJB9 mRNAPMID:28698385
Dnajb9multiple interactionsISODnajb9 (Mus musculus)6480464CTD4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of DNAJB9 mRNA]PMID:28962527
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