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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:41500
Term: 4-phenylbutyric acid
Definition: A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Chemical ID: MESH:C075773
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTD4-phenylbutyric acid results in increased expression of BAX proteinPMID:33651226
Baxmultiple interactionsEXP 6480464CTD4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [Oxygen deficiency results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of BAX protein]PMID:25450231 PMID:30980806 PMID:33651226 PMID:34214594
Baxdecreases expressionISOBax (Mus musculus)6480464CTD4-phenylbutyric acid results in decreased expression of BAX proteinPMID:25450231
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of BAX protein]]PMID:33771661
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [Silver Compounds results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]; 4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]]PMID:27816613 PMID:29306025 PMID:31364909 PMID:37148176
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