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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551095
Species: Mus musculus
RGD Object: Gene
Symbol: Rela
Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Acc ID: CHEBI:41500
Term: 4-phenylbutyric acid
Definition: A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Chemical ID: MESH:C075773
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relamultiple interactionsEXP 6480464CTD4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]PMID:28245985
Relamultiple interactionsISORELA (Homo sapiens)6480464CTD4-phenylbutyric acid inhibits the reaction [honokiol results in decreased expression of RELA protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased phosphorylation of RELA protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]PMID:28245985 PMID:34973135 PMID:36646296
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