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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10802
Species: Mus musculus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:41500
Term: 4-phenylbutyric acid
Definition: A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Chemical ID: MESH:C075773
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6decreases expressionEXP 6480464CTD4-phenylbutyric acid results in decreased expression of IL6 mRNAPMID:28698385
Il6multiple interactionsEXP 6480464CTD4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL6 protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; 4-phenylbutyric acid inhibits the reaction [SR 1078 results in increased expression of IL6 protein]PMID:28245985 PMID:28698385 PMID:35413383
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTD4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]PMID:17709599 PMID:28245985
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