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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731072
Species: Homo sapiens
RGD Object: Gene
Symbol: VEGFA
Name: vascular endothelial growth factor A
Acc ID: CHEBI:41423
Term: celecoxib
Definition: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.
Chemical ID: MESH:C105934
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
VEGFAaffects expressionEXP 6480464CTDCelecoxib affects the expression of VEGFA mRNAPMID:18438340
VEGFAdecreases expressionEXP 6480464CTDCelecoxib results in decreased expression of VEGFA; Celecoxib results in decreased expression of VEGFA proteinPMID:17224647 PMID:19024521
VEGFAincreases expressionEXP 6480464CTDCelecoxib results in increased expression of VEGFA mRNA; Celecoxib results in increased expression of VEGFA proteinPMID:21567098
VEGFAdecreases expressionISOVegfa (Mus musculus)6480464CTDCelecoxib results in decreased expression of VEGFA mRNA; Celecoxib results in decreased expression of VEGFA proteinPMID:15126378 PMID:17201140
VEGFAmultiple interactionsISOVegfa (Rattus norvegicus)6480464CTDAmpicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VEGFA mRNA]]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VEGFA mRNA]PMID:21893697
VEGFAmultiple interactionsISOVegfa (Mus musculus)6480464CTD[Celecoxib co-treated with docetaxel] results in decreased expression of VEGFA protein; Celecoxib inhibits the reaction [Dihematoporphyrin Ether results in increased expression of VEGFA protein]PMID:16052515 PMID:16230411
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