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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69169
Species: Mus musculus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:41423
Term: celecoxib
Definition: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.
Chemical ID: MESH:C105934
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargmultiple interactionsEXP 6480464CTD[Celecoxib co-treated with docetaxel] results in increased expression of PPARG proteinPMID:16052515
Ppargaffects localizationISOPPARG (Homo sapiens)6480464CTDCelecoxib affects the localization of PPARG proteinPMID:23943857
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTDCelecoxib results in increased expression of PPARG mRNA; Celecoxib results in increased expression of PPARG proteinPMID:23943857
Ppargmultiple interactionsISOPparg (Rattus norvegicus)6480464CTDCelecoxib inhibits the reaction [Dietary Fats results in decreased expression of PPARG mRNA]PMID:19247274
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [Celecoxib affects the localization of PPARG protein]; [Celecoxib results in decreased activity of and results in decreased expression of PTGS2 protein] which results in increased expression of PPARG; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Celecoxib affects the localization of PPARG protein]PMID:19522023 PMID:23943857
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