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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346183
Species: Homo sapiens
RGD Object: Gene
Symbol: BID
Name: BH3 interacting domain death agonist
Acc ID: CHEBI:41423
Term: celecoxib
Definition: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.
Chemical ID: MESH:C105934
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BIDincreases cleavageEXP 6480464CTDCelecoxib results in increased cleavage of BID proteinPMID:15197583
BIDmultiple interactionsEXP 6480464CTD[ABT-737 co-treated with Celecoxib] results in increased cleavage of BID protein; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of BID protein]PMID:15572759 PMID:20104024
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