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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:40968
Term: astaxanthin
Definition: A carotenone that consists of beta,beta-carotene-4,4'-dione bearing two hydroxy substituents at positions 3 and 3' (the 3S,3'S diastereomer). A carotenoid pigment found mainly in animals (crustaceans, echinoderms) but also occurring in plants. It can occur free (as a red pigment), as an ester, or as a blue, brown or green chromoprotein.
Chemical ID: MESH:C005948
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDastaxanthine results in increased expression of NQO1 mRNA

PMID:24157545
multiple interactionsEXP 6480464CTD[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of NQO1 mRNA, [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of NQO1 mRNA

PMID:24157545
increases expressionISORGD:25036480464CTDastaxanthine results in increased expression of NQO1 protein

PMID:20038455
multiple interactionsISORGD:25036480464CTD[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NQO1 protein

PMID:20038455
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.