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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350492
Species: Homo sapiens
RGD Object: Gene
Symbol: CYBB
Name: cytochrome b-245 beta chain
Acc ID: CHEBI:40968
Term: astaxanthin
Definition: A carotenone that consists of beta,beta-carotene-4,4'-dione bearing two hydroxy substituents at positions 3 and 3' (the 3S,3'S diastereomer). A carotenoid pigment found mainly in animals (crustaceans, echinoderms) but also occurring in plants. It can occur free (as a red pigment), as an ester, or as a blue, brown or green chromoprotein.
Chemical ID: MESH:C005948
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYBBdecreases expressionISOCybb (Rattus norvegicus)6480464CTDastaxanthine results in decreased expression of CYBB mRNAPMID:23272707
CYBBmultiple interactionsISOCybb (Rattus norvegicus)6480464CTDastaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]]PMID:23272707
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