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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621400
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:40933
Term: 5alpha-androst-16-en-3alpha-ol
Definition: A 3alpha-sterol that has formula C19H30O.
Chemical ID: MESH:C003530
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3decreases activityISORGD:15526296480464CTDandrost-16-en-3-ol results in decreased activity of NR1I3 protein

PMID:20361990
Nr1i3multiple interactionsISORGD:15526296480464CTD1 4-bis2-3 5-dichloropyridyloxybenzene inhibits the reaction [androst-16-en-3-ol results in decreased activity of NR1I3 protein] [1 4-bis2-3 5-dichloropyridyloxybenzene inhibits the reaction [androst-16-en-3-ol results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA [Endosulfan inhibits the reaction [androst-16-en-3-ol results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA

PMID:20361990
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