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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735795
Species: Mus musculus
RGD Object: Gene
Symbol: Chrnb2
Name: cholinergic receptor nicotinic beta 2 subunit
Acc ID: CHEBI:4055
Term: cytisine
Definition: An organic heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. An acetylcholine agonist, it is widely used throughout Eastern Europe as an aid to giving up smoking.
Chemical ID: MESH:C004712
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrnb2multiple interactionsISOChrnb2 (Rattus norvegicus)2303194RGDcytisine affects binding to Chrnb2 protein; cytisine competes with [Epibatidine binds to Chrnb2 protein] 
Chrnb2multiple interactionsISOChrnb2 (Rattus norvegicus)2303195RGDcytisine affects binding to Chrnb2 protein; cytisine inhibits the reaction [epibatidine affects binding to Chrnb2 protein] in rat retina 
Chrnb2affects expressionEXP 6480464CTDcytisine affects the expression of CHRNB2 proteinPMID:7756618
Chrnb2multiple interactionsEXP 6480464CTDcytisine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]PMID:7756618
Chrnb2affects bindingISOCHRNB2 (Homo sapiens)6480464CTDcytisine binds to [CHRNA4 protein binds to CHRNB2 protein]PMID:9336329
Chrnb2multiple interactionsISOCHRNB2 (Homo sapiens)6480464CTDcytisine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; cytisine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; cytisine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; pozanicline inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]PMID:14645658 PMID:20331614 PMID:9336329
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