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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735748
Species: Mus musculus
RGD Object: Gene
Symbol: Snca
Name: synuclein, alpha
Acc ID: CHEBI:4042
Term: cypermethrin
Definition: A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.
Chemical ID: MESH:C017160
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sncaincreases expressionISOSnca (Rattus norvegicus)6480464CTDcypermethrin results in increased expression of SNCA proteinPMID:25370934
Sncaincreases expressionISOSNCA (Homo sapiens)6480464CTDcypermethrin results in increased expression of SNCA mRNAPMID:27704156
Sncamultiple interactionsISOSnca (Rattus norvegicus)6480464CTDCyclosporine inhibits the reaction [cypermethrin promotes the reaction [SNCA protein binds to SNCA protein]]; Cyclosporine inhibits the reaction [cypermethrin results in increased expression of SNCA protein]; cypermethrin promotes the reaction [SNCA protein binds to SNCA protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [cypermethrin promotes the reaction [SNCA protein binds to SNCA protein]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [cypermethrin results in increased expression of SNCA protein]PMID:25370934
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