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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731002
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP3
Name: caspase 3
Acc ID: CHEBI:4042
Term: cypermethrin
Definition: A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.
Chemical ID: MESH:C017160
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP3increases activityEXP 6480464CTDcypermethrin results in increased activity of CASP3 proteinPMID:29945211
CASP3increases expressionEXP 6480464CTDcypermethrin results in increased expression of CASP3 mRNAPMID:27704156 PMID:29945211 PMID:32028016
CASP3multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [cypermethrin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [cypermethrin results in increased expression of CASP3 mRNA]; cypermethrin inhibits the reaction [Docosahexaenoic Acids results in increased cleavage of and results in increased activity of CASP3 protein]PMID:11341974 PMID:29945211
CASP3increases expressionISOCasp3 (Mus musculus)6480464CTDcypermethrin results in increased expression of CASP3 mRNAPMID:34714723
CASP3increases expressionISOCasp3 (Rattus norvegicus)6480464CTDcypermethrin results in increased expression of CASP3 mRNA; cypermethrin results in increased expression of CASP3 proteinPMID:25370934 PMID:35876585
CASP3multiple interactionsISOCasp3 (Mus musculus)6480464CTD[cypermethrin co-treated with Chlorpyrifos co-treated with profenofos] results in increased cleavage of CASP3 proteinPMID:21987380
CASP3multiple interactionsISOCasp3 (Rattus norvegicus)6480464CTD[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] affects the expression of CASP3 mRNA; cypermethrin results in increased cleavage of and results in increased activity of CASP3 protein; Quercetin inhibits the reaction [cypermethrin results in increased expression of CASP3 mRNA]; Quercetin inhibits the reaction [cypermethrin results in increased expression of CASP3 protein]PMID:22048644 PMID:34896426 PMID:35876585
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