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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:4042
Term: cypermethrin
Definition: A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.
Chemical ID: MESH:C017160
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosincreases expressionEXP 6480464CTDcypermethrin results in increased expression of FOS proteinPMID:8856738
Fosincreases expressionISOFos (Mus musculus)6480464CTDcypermethrin results in increased expression of FOS mRNA; cypermethrin results in increased expression of FOS proteinPMID:29149324
Fosmultiple interactionsISOFos (Mus musculus)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [cypermethrin results in increased expression of FOS protein]; bisindolylmaleimide I inhibits the reaction [cypermethrin results in increased expression of FOS protein]; cypermethrin inhibits the reaction [Veratridine results in increased expression of FOS mRNA]; Egtazic Acid inhibits the reaction [cypermethrin results in increased expression of FOS protein]PMID:11082455 PMID:29149324
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