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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:4042
Term: cypermethrin
Definition: A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.
Chemical ID: MESH:C017160
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects localizationEXP 6480464CTDcypermethrin affects the localization of BAX proteinPMID:25370934
Baxincreases expressionEXP 6480464CTDcypermethrin results in increased expression of BAX mRNA; cypermethrin results in increased expression of BAX proteinPMID:22048644 PMID:22528246 PMID:35876585
Baxmultiple interactionsEXP 6480464CTD[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of BAX mRNA; [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in increased expression of BAX mRNA; [fenvalerate co-treated with Allethrins co-treated with cypermethrin co-treated with decamethrin co-treated with cyhalothrin] results in decreased expression of BAX mRNA; Cyclosporine inhibits the reaction [cypermethrin affects the localization of BAX protein]; HBEGF protein inhibits the reaction [cypermethrin results in increased expression of BAX protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [cypermethrin affects the localization of BAX protein]; Quercetin inhibits the reaction [cypermethrin results in increased expression of BAX mRNA]; Quercetin inhibits the reaction [cypermethrin results in increased expression of BAX protein]PMID:22048644 PMID:25370934 PMID:33396045 PMID:34896426 PMID:35876585 PMID:36053783
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDcypermethrin results in increased expression of BAX mRNAPMID:29945211 PMID:32028016
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [cypermethrin results in increased expression of BAX mRNA]PMID:29945211
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