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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313964
Species: Homo sapiens
RGD Object: Gene
Symbol: STAT4
Name: signal transducer and activator of transcription 4
Acc ID: CHEBI:4042
Term: cypermethrin
Definition: A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.
Chemical ID: MESH:C017160
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
STAT4decreases expressionISOStat4 (Rattus norvegicus)6480464CTDcypermethrin results in decreased expression of STAT4 mRNAPMID:22528246
STAT4decreases expressionISOStat4 (Mus musculus)6480464CTDcypermethrin results in decreased expression of STAT4 mRNAPMID:31659573
STAT4multiple interactionsISOStat4 (Mus musculus)6480464CTDSodium Selenite inhibits the reaction [cypermethrin results in decreased expression of STAT4 mRNA]PMID:31659573
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