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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352960
Species: Homo sapiens
RGD Object: Gene
Symbol: CES1
Name: carboxylesterase 1
Acc ID: CHEBI:4035
Term: cyhalothrin
Definition: A carboxylic ester obtained by formal condensation between 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylic acid and cyano(3-phenoxyphenyl)methanol.
Chemical ID: MESH:C037304
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CES1increases metabolic processingEXP 6480464CTDCES1 protein results in increased metabolism of cyhalothrinPMID:19249324
CES1multiple interactionsEXP 6480464CTDCES1 protein inhibits the reaction [cyhalothrin results in increased activity of NR1I2 protein]PMID:19249324
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