Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	737448
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Cat
Name:	catalase

Acc ID:	CHEBI:4031
Term:	cyclosporin A
Definition:	A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID:	MESH:D016572

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Cat	decreases activity	ISO	Cat (Rattus norvegicus)	6480464	CTD	Cyclosporine results in decreased activity of CAT protein	PMID:17927767 PMID:19391111
Cat	decreases expression	ISO	CAT (Homo sapiens)	6480464	CTD	Cyclosporine results in decreased expression of CAT mRNA	PMID:20106945 PMID:21632981 PMID:25562108 PMID:27989131 PMID:32152650
Cat	increases activity	ISO	Cat (Rattus norvegicus)	6480464	CTD	Cyclosporine results in increased activity of CAT protein	PMID:28886988 PMID:8289993
Cat	increases expression	ISO	Cat (Rattus norvegicus)	6480464	CTD	Cyclosporine results in increased expression of CAT protein	PMID:18766458
Cat	multiple interactions	ISO	Cat (Rattus norvegicus)	6480464	CTD	[acetovanillone co-treated with CAT protein] inhibits the reaction [Cyclosporine results in increased expression of NOX4 mRNA]; [Vitamin E co-treated with Quercetin] inhibits the reaction [Cyclosporine results in decreased activity of CAT protein]; Ascorbic Acid inhibits the reaction [Cyclosporine results in decreased activity of CAT protein]; CAT protein inhibits the reaction [Cyclosporine results in increased expression of NOX4 mRNA]; Cyclosporine inhibits the reaction [3-nitropropionic acid results in decreased expression of CAT protein]; Cyclosporine inhibits the reaction [Puromycin Aminonucleoside results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Cyclosporine results in decreased activity of CAT protein]; S-allylcysteine inhibits the reaction [Cyclosporine results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Cyclosporine results in decreased activity of CAT protein]	PMID:17927767 PMID:19391111 PMID:20448265 PMID:32298299 PMID:8289993
Cat	multiple interactions	ISO	CAT (Homo sapiens)	6480464	CTD	[Cyclosporine co-treated with Cholic Acids] affects the expression of CAT mRNA; [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of CAT mRNA; Cyclosporine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]	PMID:27344345 PMID:32135237 PMID:32152650

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