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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737202
Species: Homo sapiens
RGD Object: Gene
Symbol: FLT1
Name: fms related receptor tyrosine kinase 1
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FLT1decreases expressionEXP 6480464CTDCyclosporine results in decreased expression of FLT1 mRNAPMID:33631201
FLT1increases expressionISOFlt1 (Rattus norvegicus)6480464CTDCyclosporine results in increased expression of FLT1 mRNAPMID:12110003
FLT1multiple interactionsISOFlt1 (Rattus norvegicus)6480464CTD[Hydralazine co-treated with Hydrochlorothiazide] inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA]; nilvadipine inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA]PMID:12110003
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