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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736485
Species: Mus musculus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1decreases expressionEXP 6480464CTDCyclosporine results in decreased expression of SQSTM1 proteinPMID:33689844
Sqstm1increases expressionEXP 6480464CTDCyclosporine results in increased expression of SQSTM1 mRNAPMID:19770486
Sqstm1increases expressionISOSqstm1 (Rattus norvegicus)6480464CTDCyclosporine results in increased expression of SQSTM1 mRNAPMID:25596134
Sqstm1increases expressionISOSQSTM1 (Homo sapiens)6480464CTDCyclosporine results in increased expression of SQSTM1 mRNAPMID:20106945 PMID:25562108 PMID:25596134 PMID:27989131 PMID:32152650 PMID:34681664
Sqstm1multiple interactionsISOSQSTM1 (Homo sapiens)6480464CTD[Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of SQSTM1 mRNA; Cyclosporine inhibits the reaction [quinone results in decreased expression of SQSTM1 protein]PMID:29567065 PMID:32152650
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