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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69210
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP7A1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP7A1decreases expressionEXP 6480464CTDCyclosporine results in decreased expression of CYP7A1 mRNA; Cyclosporine results in decreased expression of CYP7A1 proteinPMID:20106945 PMID:26198044 PMID:32152650 PMID:32253466 PMID:34681664
CYP7A1multiple interactionsEXP 6480464CTD[Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of CYP7A1 mRNA; [Cyclosporine results in decreased expression of CYP7A1 protein] which affects the abundance of Cholic AcidsPMID:26198044 PMID:32152650
CYP7A1increases expressionISOCyp7a1 (Mus musculus)6480464CTDCyclosporine results in increased expression of CYP7A1 mRNAPMID:19770486
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