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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69169
Species: Mus musculus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargaffects activityISOPparg (Rattus norvegicus)6480464CTDCyclosporine affects the activity of PPARG proteinPMID:25596134
Ppargaffects activityISOPPARG (Homo sapiens)6480464CTDCyclosporine affects the activity of PPARG proteinPMID:25596134
Ppargdecreases expressionISOPparg (Rattus norvegicus)6480464CTDCyclosporine results in decreased expression of PPARG mRNA; Cyclosporine results in decreased expression of PPARG proteinPMID:17461532
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTDCyclosporine results in increased expression of PPARG mRNAPMID:20106945
Ppargmultiple interactionsISOPparg (Rattus norvegicus)6480464CTDCyclosporine inhibits the reaction [rosiglitazone results in increased expression of PPARG protein]; rosiglitazone inhibits the reaction [Cyclosporine results in decreased expression of PPARG mRNA]; rosiglitazone inhibits the reaction [Cyclosporine results in decreased expression of PPARG protein]PMID:17461532
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTD[Sirolimus co-treated with Cyclosporine] results in decreased expression of PPARG proteinPMID:17016853
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