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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDCyclosporine results in decreased expression of CCND1 mRNA

PMID:19224547
decreases expressionISORGD:685566480464CTDCyclosporine results in decreased expression of CCND1 mRNA, Cyclosporine results in decreased expression of CCND1 protein

PMID:19159671, PMID:24244623, PMID:27989131
multiple interactionsISORGD:685566480464CTD[Cyclosporine co-treated with NGF protein] results in decreased expression of CCND1 mRNA, [Cyclosporine co-treated with NGF protein] results in decreased expression of CCND1 protein, Cyclosporine inhibits the reaction [sodium arsenite results in increased expression of CCND1 protein]

PMID:24244623, PMID:29528074
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.