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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620312
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppib
Name: peptidylprolyl isomerase B
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppibdecreases expressionISOPPIB (Homo sapiens)6480464CTDCyclosporine results in decreased expression of PPIB mRNAPMID:27989131
Ppibdecreases expressionISOPpib (Mus musculus)6480464CTDCyclosporine results in decreased expression of PPIB proteinPMID:23308384 PMID:25047351
Ppibincreases expressionISOPPIB (Homo sapiens)6480464CTDCyclosporine results in increased expression of PPIB mRNAPMID:20106945 PMID:21632981 PMID:25562108
Ppibincreases expressionISOPpib (Mus musculus)6480464CTDCyclosporine results in increased expression of PPIB mRNAPMID:25047351
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