Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332312
Species: Mus musculus
RGD Object: Gene
Symbol: Xbp1
Name: X-box binding protein 1
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xbp1increases expressionEXP 6480464CTDCyclosporine results in increased expression of XBP1 mRNA; Cyclosporine results in increased expression of XBP1 protein modified formPMID:23958496 PMID:25270620
Xbp1multiple interactionsEXP 6480464CTDCyclosporine results in increased expression of and affects the localization of XBP1 protein modified formPMID:23958496
Xbp1affects activityISOXbp1 (Rattus norvegicus)6480464CTDCyclosporine affects the activity of XBP1 proteinPMID:25596134
Xbp1affects activityISOXBP1 (Homo sapiens)6480464CTDCyclosporine affects the activity of XBP1 proteinPMID:25596134
Xbp1decreases expressionISOXbp1 (Rattus norvegicus)6480464CTDCyclosporine results in decreased expression of XBP1 mRNAPMID:25596134
Xbp1increases expressionISOXBP1 (Homo sapiens)6480464CTDCyclosporine results in increased expression of XBP1 mRNA; Cyclosporine results in increased expression of XBP1 protein alternative formPMID:25596134 PMID:35033536
Xbp1increases splicingISOXBP1 (Homo sapiens)6480464CTDCyclosporine results in increased splicing of XBP1 mRNAPMID:35033536
Xbp1multiple interactionsISOXBP1 (Homo sapiens)6480464CTDATF6 protein affects the reaction [Cyclosporine results in increased expression of XBP1 protein alternative form]PMID:35033536
Go Back to source page   Continue to Ontology report