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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pten
Name: phosphatase and tensin homolog
Acc ID: CHEBI:40303
Term: lovastatin
Definition: A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).
Chemical ID: MESH:D008148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptenincreases expressionEXP 6480464CTDLovastatin results in increased expression of PTEN mRNAPMID:20578043
Ptenmultiple interactionsEXP 6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [Lovastatin results in increased expression of PTEN mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PTEN mRNA]; Lovastatin results in increased expression of and results in increased phosphorylation of PTEN protein; PTEN protein affects the reaction [Lovastatin results in increased expression of MBP mRNA]; PTEN protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA]PMID:20578043
Ptenincreases expressionISOPten (Mus musculus)6480464CTDLovastatin results in increased expression of PTEN proteinPMID:16425225
Ptenincreases expressionISOPTEN (Homo sapiens)6480464CTDLovastatin results in increased expression of PTEN proteinPMID:16425225
Ptenmultiple interactionsISOPten (Mus musculus)6480464CTDPPARG affects the reaction [Lovastatin results in increased expression of PTEN protein]PMID:16425225
Ptenmultiple interactionsISOPTEN (Homo sapiens)6480464CTDCycloheximide inhibits the reaction [Lovastatin results in increased expression of PTEN protein]; PPARG protein affects the reaction [Lovastatin results in increased expression of PTEN protein]PMID:16425225
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