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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2129
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Apob
Name: apolipoprotein B
Acc ID: CHEBI:40303
Term: lovastatin
Definition: A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).
Chemical ID: MESH:D008148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Apobdecreases secretionISOAPOB (Homo sapiens)6480464CTDLovastatin results in decreased secretion of APOB proteinPMID:11728391
Apobmultiple interactionsISOAPOB (Homo sapiens)6480464CTD[Niacin co-treated with Lovastatin] results in decreased expression of APOB proteinPMID:12633795
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