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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:40303
Term: lovastatin
Definition: A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).
Chemical ID: MESH:D008148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7368326480464CTDLovastatin inhibits the reaction [EGF protein promotes the reaction [EGFR protein results in increased phosphorylation of EGFR protein]], Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein], Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein], Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein], Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein], Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of RAF1 protein]

PMID:12942316, PMID:19760159
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.