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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10357
Species: Mus musculus
RGD Object: Gene
Symbol: Chrna7
Name: cholinergic receptor, nicotinic, alpha polypeptide 7
Acc ID: CHEBI:40303
Term: lovastatin
Definition: A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).
Chemical ID: MESH:D008148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna7increases expressionISOChrna7 (Rattus norvegicus)6480464CTDLovastatin results in increased expression of CHRNA7 mRNA; Lovastatin results in increased expression of CHRNA7 proteinPMID:29341888
Chrna7multiple interactionsISOChrna7 (Rattus norvegicus)6480464CTDU 0126 inhibits the reaction [Lovastatin results in increased expression of CHRNA7 protein]PMID:29341888
Chrna7multiple interactionsISOCHRNA7 (Homo sapiens)6480464CTD[Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein]PMID:29341888
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