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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735941
Species: Homo sapiens
RGD Object: Gene
Symbol: CREM
Name: cAMP responsive element modulator
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CREMdecreases expressionISOCrem (Rattus norvegicus)6480464CTDCyclophosphamide results in decreased expression of CREM mRNA; Cyclophosphamide results in decreased expression of CREM proteinPMID:17624719
CREMmultiple interactionsISOCrem (Rattus norvegicus)6480464CTDDrugs, Chinese Herbal inhibits the reaction [Cyclophosphamide results in decreased expression of CREM mRNA]; Drugs, Chinese Herbal inhibits the reaction [Cyclophosphamide results in decreased expression of CREM protein]PMID:17624719
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