GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | NFE2L2 | decreases expression | ISO | Nfe2l2 (Rattus norvegicus) | 6480464 | CTD | Cyclophosphamide results in decreased expression of NFE2L2 mRNA; Cyclophosphamide results in decreased expression of NFE2L2 protein | PMID:20038455 PMID:20433640 PMID:32456565 | NFE2L2 | increases expression | ISO | Nfe2l2 (Rattus norvegicus) | 6480464 | CTD | Cyclophosphamide results in increased expression of NFE2L2 mRNA; Cyclophosphamide results in increased expression of NFE2L2 protein | PMID:20038455 PMID:37419146 | NFE2L2 | increases response to substance | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | NFE2L2 gene mutant form results in increased susceptibility to Cyclophosphamide | PMID:27633142 | NFE2L2 | multiple interactions | ISO | Nfe2l2 (Rattus norvegicus) | 6480464 | CTD | [astaxanthine co-treated with Cyclophosphamide] results in increased expression of NFE2L2 protein; Cilostazol inhibits the reaction [Cyclophosphamide results in decreased expression of NFE2L2 mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NFE2L2 protein]; Quercetin inhibits the reaction [Cyclophosphamide results in increased expression of NFE2L2 mRNA] | PMID:20038455 PMID:20433640 PMID:32456565 PMID:37419146 | NFE2L2 | multiple interactions | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of CAT protein]; Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of GCLC protein]; Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of NQO1 protein]; NFE2L2 gene mutant form inhibits the reaction [Cyclophosphamide results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form promotes the reaction [Cyclophosphamide results in decreased expression of CAT protein]; NFE2L2 gene mutant form promotes the reaction [Cyclophosphamide results in decreased expression of NQO1 protein] | PMID:27633142 | |
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