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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730872
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD2
Name: superoxide dismutase 2
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD2affects response to substanceEXP 6480464CTDSOD2 polymorphism affects the susceptibility to CyclophosphamidePMID:20309628
SOD2decreases expressionISOSod2 (Rattus norvegicus)6480464CTDCyclophosphamide results in decreased expression of SOD2 mRNAPMID:11906922
SOD2increases expressionISOSod2 (Mus musculus)6480464CTDCyclophosphamide results in increased expression of SOD2 mRNAPMID:15331540
SOD2increases expressionISOSod2 (Rattus norvegicus)6480464CTDCyclophosphamide results in increased expression of SOD2 mRNAPMID:11599041
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