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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1562112
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Foxp3
Name: forkhead box P3
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Foxp3decreases expressionISOFoxp3 (Mus musculus)6480464CTDCyclophosphamide results in decreased expression of FOXP3 mRNA; Cyclophosphamide results in decreased expression of FOXP3 proteinPMID:15591121 PMID:32151603
Foxp3multiple interactionsISOFoxp3 (Mus musculus)6480464CTDFungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of FOXP3 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of FOXP3 protein]PMID:32151603
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