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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1343759
Species: Homo sapiens
RGD Object: Gene
Symbol: CXCL1
Name: C-X-C motif chemokine ligand 1
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL1affects expressionISOCxcl3 (Mus musculus)6480464CTDCyclophosphamide affects the expression of CXCL3 mRNAPMID:18957084
CXCL1increases expressionISOCxcl3 (Mus musculus)6480464CTDCyclophosphamide results in increased expression of CXCL1 mRNA; Cyclophosphamide results in increased expression of CXCL1 proteinPMID:15331540 PMID:18483878
CXCL1increases expressionISOCxcl1 (Rattus norvegicus)6480464CTDCyclophosphamide results in increased expression of CXCL1 proteinPMID:18848347
CXCL1multiple interactionsISOCxcl3 (Mus musculus)6480464CTDVIP protein inhibits the reaction [Cyclophosphamide results in increased expression of CXCL1 protein]PMID:18483878
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