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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3931
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ucp1
Name: uncoupling protein 1
Acc ID: CHEBI:4021
Term: Cyclopamine
Definition: A piperidine that has formula C27H41NO2.
Chemical ID: MESH:C000541
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ucp1multiple interactionsISOUCP1 (Homo sapiens)6480464CTDcyclopamine inhibits the reaction [N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine results in increased expression of UCP1 mRNA]; cyclopamine inhibits the reaction [tofacitinib results in increased expression of UCP1 mRNA]PMID:25487280
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