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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:40071
Term: 4-amino-1,8-naphthalimide
Definition: A benzoisoquinoline that has formula C12H8N2O2.
Chemical ID: MESH:C086538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1decreases activityISORGD:15519886480464CTD4-amino-1,8-naphthalimide results in decreased activity of PARP1 proteinPMID:16556909
Parp1decreases expressionISORGD:13451186480464CTD4-amino-1,8-naphthalimide results in decreased expression of PARP1 proteinPMID:25499136
Parp1multiple interactionsISORGD:13451186480464CTD4-amino-1,8-naphthalimide inhibits the reaction [Doxorubicin results in increased activity of PARP1 protein]PMID:15456408
Parp1multiple interactionsISORGD:15519886480464CTDATM protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]; PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of ATM protein]; PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of CHEK2 protein]; PRKDC protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]PMID:16556909
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