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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737416
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2C19
Name: cytochrome P450 family 2 subfamily C member 19
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2C19decreases expressionEXP 6480464CTDValproic Acid results in decreased expression of CYP2C19 mRNAPMID:29154799
CYP2C19decreases methylationEXP 6480464CTDValproic Acid results in decreased methylation of CYP2C19 genePMID:29154799
CYP2C19increases expressionEXP 6480464CTDValproic Acid results in increased expression of CYP2C19 mRNAPMID:25084468
CYP2C19increases response to substanceEXP 6480464CTDCYP2C19 protein results in increased susceptibility to Valproic AcidPMID:28762043
CYP2C19affects expressionISOCyp2c38 (Mus musculus)6480464CTDValproic Acid affects the expression of CYP2C38 mRNAPMID:17963808
CYP2C19increases expressionISOCyp2c6 (Rattus norvegicus)6480464CTDValproic Acid results in increased expression of CYP2C6V1 mRNAPMID:35594946
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