GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PDE4A | increases expression | EXP | | 6480464 | CTD | Valproic Acid results in increased expression of PDE4A mRNA | PMID:19101580 PMID:23179753 PMID:27188386 | PDE4A | increases methylation | EXP | | 6480464 | CTD | Valproic Acid results in increased methylation of PDE4A gene | PMID:29154799 | PDE4A | decreases expression | ISO | Pde4a (Rattus norvegicus) | 6480464 | CTD | Valproic Acid results in decreased expression of PDE4A protein | PMID:20222156 | |
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