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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733814
Species: Mus musculus
RGD Object: Gene
Symbol: Bnip3
Name: BCL2/adenovirus E1B interacting protein 3
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDValproic Acid affects the expression of BNIP3 mRNA

PMID:17292431, PMID:17963808
affects expressionISORGD:13509136480464CTDValproic Acid affects the expression of BNIP3 mRNA

PMID:25979313
decreases expressionISORGD:13509136480464CTDValproic Acid results in decreased expression of BNIP3 mRNA

PMID:19949822, PMID:23179753, PMID:27188386
increases expressionISORGD:13509136480464CTDValproic Acid results in increased expression of BNIP3 mRNA

PMID:23179753, PMID:24383497, PMID:24935251, PMID:25446377, PMID:26272509, PMID:28001369
increases methylationISORGD:13509136480464CTDValproic Acid results in increased methylation of BNIP3 gene

PMID:29154799
multiple interactionsISORGD:13509136480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BNIP3 mRNA, benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Valproic Acid results in increased expression of BNIP3 mRNA], Valproic Acid results in increased expression of and affects the localization of BNIP3 protein, Vincristine affects the reaction [Valproic Acid affects the localization of BNIP3 protein]

PMID:25446377, PMID:27188386
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.