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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732227
Species: Homo sapiens
RGD Object: Gene
Symbol: NR3C1
Name: nuclear receptor subfamily 3 group C member 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR3C1decreases methylationEXP 6480464CTDValproic Acid results in decreased methylation of NR3C1 genePMID:29154799
NR3C1increases expressionEXP 6480464CTDValproic Acid results in increased expression of NR3C1 mRNAPMID:23179753 PMID:24383497 PMID:26272509 PMID:26705709 PMID:27188386 PMID:28001369
NR3C1multiple interactionsEXP 6480464CTD[Hydralazine co-treated with Valproic Acid] results in increased expression of NR3C1 mRNA; [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NR3C1 mRNAPMID:17183730 PMID:27188386
NR3C1decreases expressionISONr3c1 (Mus musculus)6480464CTDValproic Acid results in decreased expression of NR3C1 proteinPMID:15249158
NR3C1multiple interactionsISONr3c1 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Valproic Acid inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]]; pyrazolanthrone inhibits the reaction [Valproic Acid inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]]; Valproic Acid inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]PMID:15249158
NR3C1multiple interactionsISONr3c1 (Rattus norvegicus)6480464CTDValproic Acid inhibits the reaction [Dexamethasone affects the localization of and results in increased activity of NR3C1 protein]PMID:15872096
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