GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 728895
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Trhde
Name: thyrotropin-releasing hormone degrading enzyme
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7309366480464CTDValproic Acid affects the expression of TRHDE mRNA

PMID:25979313
decreases expressionISORGD:7309376480464CTDValproic Acid results in decreased expression of TRHDE mRNA

PMID:24896083
decreases methylationISORGD:7309366480464CTDValproic Acid results in decreased methylation of TRHDE gene

PMID:29154799
increases expressionISORGD:7309366480464CTDValproic Acid results in increased expression of TRHDE mRNA

PMID:23179753, PMID:24383497, PMID:26272509, PMID:28001369
multiple interactionsISORGD:7309366480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRHDE mRNA

PMID:27188386
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.