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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70824
Species: Homo sapiens
RGD Object: Gene
Symbol: MET
Name: MET proto-oncogene, receptor tyrosine kinase
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
METincreases expressionEXP 6480464CTDValproic Acid results in increased expression of MET mRNAPMID:23179753 PMID:24383497 PMID:26238599 PMID:26272509 PMID:28001369 PMID:32816093
METmultiple interactionsEXP 6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MET mRNAPMID:27188386
METdecreases expressionISOMet (Rattus norvegicus)6480464CTDValproic Acid results in decreased expression of MET mRNAPMID:33150595
METincreases methylationISOMet (Rattus norvegicus)6480464CTDValproic Acid results in increased methylation of MET promoterPMID:33150595
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