Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:694736480464CTDValproic Acid affects the expression of SREBF1 mRNA

PMID:25979313
affects expressionISORGD:694746480464CTDValproic Acid affects the expression of SREBF1 mRNA

PMID:17292431, PMID:17963808
decreases expressionISORGD:694736480464CTDValproic Acid results in decreased expression of SREBF1 mRNA

PMID:29154799
increases expressionISORGD:694736480464CTDValproic Acid results in increased expression of SREBF1 mRNA, Valproic Acid results in increased expression of SREBF1 protein

PMID:25716160, PMID:27089845, PMID:30003287
multiple interactionsISORGD:694736480464CTDNR1H3 protein affects the reaction [Valproic Acid results in increased expression of SREBF1 mRNA], NR1H3 protein promotes the reaction [Valproic Acid results in increased expression of SREBF1 mRNA]

PMID:30003287
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.